Cardiovascular Inflammation
نویسندگان
چکیده
Westernized countries face a growing burden of cardiovascular diseases including acute complications of coronary atherosclerosis. Cardiovascular diseases often associate with metabolic disorders such as insulin resistance and obesity. Emerging clinical and experimental studies suggest that inflammation is central to the development of these cardiometabolic disorders. A proinflammatory subset of monocytes/macrophages may importantly contribute to pathological processes in cardiometabolic organs. Crosstalks between cardiometabolic organs may enhance systemic and local inflammatory milieu. In addition, accumulating evidence supports a key role for inflammation in the pathogenesis of vascular mineral deposition and calcific aortic valve stenosis. The goal of this special issue is to highlight what is known concerning the inflammatory nature of cardiovascular diseases, such as atherosclerosis and aortic valve calcification, and their association with metabolic disorders. Armed with this understanding, it is hoped that novel therapeutic strategies will aid in the prevention and management of the cardiometabolic syndrome and its complications, and benefit the patients afflicted with calcific aortic valve disease.
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عنوان ژورنال:
دوره 2012 شماره
صفحات -
تاریخ انتشار 2012